KNOW THE DIFFERENCE: BIOREGULATOR PEPTIDES are NOT simply Extracts 👉🏿 and extracts are clearly not bioregulator peptides
- docbinah
- Sep 5
- 7 min read
Updated: Oct 9
by Robin Rose MD - September 5, 2025
It has come to my attention that there are products being sold as bioregulator peptides… that …ARE NOT…bioregulators. I want to clarify this marketing deception.
It is time for clinicians and patients alike to know the difference between a bioregulator peptide and a glandular extract.
Big difference. Let’s look.
So first - what is an extract ?
Definition they imply: Any organ-derived peptide mixture that may “support regulation” of organ function.
Product type: Organ extracts / ultrafiltrates containing many small peptides + proteins + metabolites.
Labeling: Called “natural peptide bioregulators.”
Reality: More like refined glandular supplements — supportive, trophic, broad activity.
Clinical action: General nourishment of organ cells; may aid resilience, but not targeted gene control.
And then compare this to true bioregulator peptides
Short, purified peptides (2–4 amino acids) with known sequences, discovered and sequenced from organ tissue.
Product type: Chemically synthesized or purified defined peptides (e.g., Pielotax, Epitalon, Vilon etc).
Labeling: “Cytomaxes,” “Cytogens,” or “bioregulator peptides.”
Reality: True gene switches — they bind DNA/histones, restore protein synthesis, and epigenetically reprogram aging or damaged cells.
Clinical action: Reproducible, organ-specific regulation (kidney, thymus, pineal, etc.) with 40+ years of published research.: Short, purified peptides (2–4 amino acids) with known sequences, discovered and sequenced from organ tissue.
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The peptides discovered by Vladimir Khavinson and his team in St, Petersburg are true bioregulators in the pharmacological sense, with proven, reproducible gene-switching effects.
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Let’s take a deeper look 👁️
at what’s happening👁️
One company describes their so-called bioregulator products as “natural peptide bioregulators” - claiming that these are ultrafiltrates of animal organs, produced under GMP/ISO conditions, and meant to support cellular protein synthesis.
Okay but that does not put them in the category of bioregulators.
They use the term “bioregulator” in a marketing sense — i.e., “supports regulation of the organ,” rather than in the strict scientific and pharmacological sense of the Russian Khavinson peptides (where a bioregulator is a defined short peptide with gene-switching activity).
The reality
These organ extract ultrafiltrates contain small peptides, but it is a mixture — not an isolated peptide with a known sequence, not reproducible as a “gene switch.” Pharmacologically, it behaves like a refined glandular extract, not like known bioregulator peptides like Pielotax or Epitalon.
So yes…
These companies are deceptively advertising an extract as a “peptide bioregulator.”
Although short peptides are present (and they can influence biology) - it is clearly misleading if one assumes it means they are the defined Russian bioregulators with proven gene-switch activity.
These organ extracts are closer to modern glandulars. True bioregulators like Pielotax are defined peptides with reproducible gene-switching effects.
That distinction matters clinically.
👉🏿Clinical Contrast👈🏿
Extracts = trophic soup: Supportive, nutritive, less predictable, not direct gene modulators.
Bioregulators = gene switches: Precisely regulate transcription of life supporting proteins in a targeted organ, with reproducible and specific outcomes. (With aging and illness there is decline or cessation of transcription and production of vital life supporting proteins- the bioregulator peptides uniquely reverse this unfortunate decline).
Extracts vs. Bioregulator Peptides: Gene Regulation is the Key
Organ Extracts/Glandulars/Ultrafiltrates
What they contain: A mixture of small peptides, amino acids, proteins, nucleotides, and metabolites.
Pharmacology:
They may provide trophic support by delivering building blocks.
Some peptides might act as general signaling molecules (immune modulation, nutrient sensing).
But 👉🏿 there is no evidence they bind DNA or histones in a targeted way!!!
Key point: They do not function as “gene switches.” Their effects are broad, nutritional, and supportive, not specific transcriptional regulators.
Peptide Bioregulators (Defined Peptides like Pielotax, Epitalon, Vilon)
What they contain: Short, purified peptides with known amino acid sequences (often 2–4 AAs long).
Pharmacology:
These peptides have been shown (by the St. Petersburg group with more than 40 years of research) to penetrate the nucleus and bind to specific DNA sites or histone proteins.
This allows them to act as “gene switches” — modulating transcription, repairing protein synthesis programs, and restoring tissue homeostasis.
The effects are organ-specific (kidney peptides act on nephron gene expression, thymus peptides on immune genes, etc.)
Key point: These are true gene modulators, with reproducible, targeted, and clinically documented effects. This means that epigenetic damage is repaired by these gene switching agents.
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To Simplify the phrasing:
“Extracts feed the organ.”
“Bioregulators reprogram the organ.”
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Clinical Implications of Extract vs Bioregulator Production
1. Reproducibility of Effect
Extracts (organ/glandulars):
Variable composition → variable results.
Patient responses can be unpredictable: one may feel energized, another nothing at all, another GI upset.
Hard to study in clinical trials because the active principle is undefined.
Bioregulators (defined peptides):
Every capsule/injection contains the same peptide sequence.
Effects are reproducible and target-specific (e.g., Pielotax → nephron gene expression, Epitalon → pineal/melatonin regulation, Vilon → immune normalization).
Clinical outcomes are more consistent across populations.
2. Mechanistic Precision
Extracts: Work as “nutrient signaling soups” → support organ trophism, may provide cofactors and peptide fragments that generally nourish the target tissue.
Bioregulators: Act as direct gene regulators → up-regulate protein synthesis in specific cells, repair DNA transcription, normalize protein turnover. This gives a drug-like precision. This is epigenetic repair!
3. Side Effects & Safety
Extracts (glandulars/ultrafiltrates):
Potential risks:
Immunogenicity: Larger or variable peptides/proteins may trigger immune reactivity (antibodies, inflammation, or rarely autoimmunity if poorly processed).
Allergic reactions: Because they are less purified, animal proteins or glycoproteins may provoke allergy.
Batch contaminants: Heavy metals, prions, residual endotoxins, if not stringently filtered. (Reputable GMP labs reduce this risk, but not every supplier meets the same standard.)
GI upset: Nausea, bloating, diarrhea in sensitive patients — more common with extracts than defined peptides.
Bioregulators (purified peptides):
Safety profile is very clean:
Short peptides (2–4 amino acids) → rapidly absorbed and metabolized.
Too small to provoke immune recognition → essentially non-immunogenic.
Decades of clinical use in Russia and Europe show no significant side effects even with long-term administration.
Main risk of bioregulators: sourcing from unreliable vendors (purity issues, mislabeled products).
Clinical Summary
Extracts are safe when GMP-certified, but effects are broad, less reproducible, and may occasionally cause GI upset or allergy. Think of them as organ trophic support — like a “nutrient glandular.”
Bioregulators are pharmacologically potent and precise. They act at the level of gene regulation, with clean safety and reproducibility. Clinical data support their role in organ repair and aging delay.
What’s the Key Difference
👉🏿Bioregulator peptides = ultra-short, sequence-verified, purified molecules → act as gene switches.
👉🏿Extracts/glandulars = crude protein/peptide mixtures → act as nutritional support or immune stimulants, not precise gene modulators.
🍃 Bioregulator Source Materials
Cytomaxes (natural complexes): Derived from animal organs (e.g., kidney, liver, pineal gland) but subjected to rigorous low-temperature water–salt extraction, preserving only ultra-short peptides (2–4 amino acids) and eliminating large proteins, lipids, and potential contaminants.
Cytogens (synthetic analogues): Produced by solid-phase peptide synthesis (SPPS) in the lab, copying the active short peptides discovered in Cytomaxes.
Cytamins (less refined, nucleoprotein fractions): Contain peptides plus nucleic acids; they are closer to crude extracts but still standardized.
🍃Extraction and Isolation (for natural peptides) 👉🏿 this takes many months
Tissue collection from certified, pathogen-free animal sources.
Low-temperature aqueous extraction (avoids denaturing peptides).
Fractionation to separate peptides from proteins, nucleic acids, and other macromolecules.
Ultrafiltration and dialysis: Ensures only low-molecular-weight peptides (≤10 kDa, but usually <1 kDa for bioregulators) are retained.
Lyophilization (freeze-drying) for stability and standardization.
🍃Synthetic Production (for Cytogens)
Solid-phase peptide synthesis (SPPS):
A resin is used to sequentially add amino acids in the correct order.
Protecting groups (like Fmoc or Boc chemistry) prevent unwanted side reactions.
After elongation, peptides are cleaved off the resin, deprotected, and purified.
Purification is done by high-performance liquid chromatography (HPLC)
Characterization involves mass spectrometry and NMR spectroscopy to verify purity and structure.
🍃Purification and Quality Control
Sterile filtration and removal of endotoxins (critical to differentiate from organ extracts, which may retain pyrogens)
Analytical testing for peptide sequence confirmation, molecular weight, and activity.
Batch consistency testing: Ensures each vial has the exact same active peptide sequences.
🍃Formulation
Peptides are stabilized as oral tablets, capsules, sprays, or injectables, sometimes bound to stabilizers (e.g., lactose, cellulose).
For injectables, they must meet pharmaceutical GMP standards: isotonicity, sterility, and stability over shelf life.
🍃Pharmacological Distinction
Because of this production, bioregulator peptides are not glandular extracts.
They are defined molecules with reproducible action as epigenetic modulators (turning on/off specific DNA expression).
Extracts being marketed as bioregulator peptides contain a mix of proteins and peptides without purification or defined sequence. 👉🏿These can trigger immune or allergic reactions, whereas true bioregulators rarely do.
👉🏿🧐Bottom Line🧐👈🏿
“Extracts are more like food supplements for the kidney or other organs. They can be helpful but may be inconsistent, and in rare cases cause mild side effects.
Bioregulators are defined peptides — they work like a switch on the genetic program, with decades of safe use and highly reproducible effects.
What’s the Key Difference
Bioregulator peptides = ultra-short, sequence-verified, purified molecules → act as gene switches.
Extracts/glandulars = crude protein/peptide mixtures → act as nutritional support or immune stimulants, not precise gene modulators.
CONCLUSION: so what to do?
NAVIGATE cautiously - choose health and purity.
My personal choice of bioregulator products has been Profound Health for their commitment to pure products with less fillers than other companies - with kidney that really matters. Reading the fine print really matters. Some companies are not transparent with their formulation or fillers - in fulfilling the intent for kidney success - that’s unacceptable.
Here’s a link for Profound Heath
Including an array of various bioregulator peptides in a lifestyle-devoted CKD regimen is incredibly useful to achieve RENOLOGY goals. Not just kidney (pielotax) but blood vessel, heart, brain, liver, parathyroid, thyroid, stomach, pineal, thymus… and on and on - see my book RENOLOGY Peptides for truly learning how to manage CKD with the wonderful inclusion of bioregulator peptides. Starting as early as possible vs waiting until advanced decline is the wisdom that we all must promote!!!
But sadly not enough physicians or other clinicians have learned how to use these bioregulators in a precision and personalized manner - yet!!
Remember ckd influences all the cells in the body - and a combination of bioregulators cycled and pulsed can make a remarkable difference over time.
Together we can achieve kidney success!
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